The HP-1alpha Mouse mAb (1E8) Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The HP-1alpha Mouse mAb (1E8) Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ' Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins